Methylmagnesium bromide solution CAS 75-16-1

Methylmagnesium bromide solution CAS 75-16-1

Bromomethylmagnesium

Methylmagnesium bromide solution CAS75-16-1
CAS:75-16-1           MW:119.24
Linear Formula:CH3MgBr
CAS Number:75-16-1
Molecular Weight:119.24
Beilstein:3535220
MDL number:MFCD00000041
UNSPSC Code:12352111

 

reaction suitabilityreaction type: Grignard Reaction
concentration3.0 M in diethyl ether
density1.035 g/mL at 25 °C
SMILES stringC[Mg]Br
InChI1S/CH3.BrH.Mg/h1H3;1H;/q;;+1/p-1
InChI keyAVFUHBJCUUTGCD-UHFFFAOYSA-M

 

Description:

Methylmagnesium bromide solution, also known as bromomethylmagnesium, is both a Lewis acid and nucleophile. It is commonly used as a grignard reagent in organic synthesis reactions. 

Application:

Methylmagnesium bromide solution (3M in diethyl ether) is used to synthesize:

3S-(Boc-amino)-2,4-dimethyl-2-pentanol and methyl tert-butyl (S)-sulfoxide. 

Methyl potassium polyimide (K-PIM-1) (MeMgBr).

3(4R)-{3(2R,3S)-[4′-(1′-triphenylmethyl)imidazole]-2-bromo-1-oxobutyl)-4-phenyl2-oxazolidinone

Benzyl 2-(2-oxopropyl)piperidine-1-carboxylate

(R*, R*) 1-[1-(1-phenylethyl)pyrrolidin-2-yl]propan-2-one)

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