Fmoc-Lys(Pal-Glu-OtBu)-OH CAS 1491158-62-3
Fmoc-Lys(Pal-Glu-OtBu)-OH CAS 1491158-62-3
Liraglutide Lys;Fmoc-Lys(Pal-Glu-OtBu);Fmoc-Lys(Pal-Glu-OtBu)-OH;Palm-Glu(Ot-Bu)-Fmoc-Lys-OH;Fmoc-L-Lys(Palm-L-Glu-OtBu)-OH;PLU-3(Fmoc-L-Lys(Palm-L-Glu-Otbu)-OH);Fmoc-L-Lys(Palm-L-Glu-OtBu)-OH main building block;(9H-Fluoren-9-yl)MethOxy]Carbonyl Lys(Pal-Glu-OtBu)-OH;N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-((S)-5-(tert-butoxy)-5-oxo-4-palmitamidopentanoyl)-L-lysine;N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-(N-alpha’-palmitoyl-L-glutamic-acid alpha’-t-butyl ester)-L-lysine
| CAS No. | 1491158-62-3 |
| Chemical Name: | Fmoc-Lys(Pal-Glu-OtBu)-OH |
| CBNumber: | CB13054762 |
| Molecular Formula: | C46H69N3O8 |
| Molecular Weight: | 792.06 |
| MDL Number: | MFCD27952849 |
| Boiling point | 944.2±65.0 °C(Predicted) |
| Density | 1.099±0.06 g/cm3(Predicted) |
| storage temp. | Storage temp. 2-8°C |
| form | Solid |
| pka | 3.88±0.21(Predicted) |
| color | White to off-white |
| InChIKey | SUFBOZUGILQOQW-FMQAFZDONA-N |
| SMILES | C(O)(=O)[C@@H](N(C1C2=C(C=CC=C2)C2=C1C=CC=C2)C(OC)=O)CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(OC(C)(C)C)=O |&1:3,31,r| |
Application:
Fmoc-Lys(Pal-Glu-OtBu)-OH is a racemic, solid-phase, industrial building block for the synthesis of peptides and polypeptides. This product is used in the synthesis of liraglutide (a peptide), which is used to treat type 2 diabetes mellitus. It is synthesized by a solid phase process using coupling reactions with an acid labile linker. This product has been shown to be an efficient building block for the synthesis of peptides and polypeptides that have a sequence that can be varied by changing the protecting group on the amino acid.
Uses1:
Fmoc-Lys(Pal-Glu-OtBu)-OH can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Uses2:
Fmoc-Lys (Pal-Glu-OtBu)-OH is a non-cleavable antibody-drug conjugates linker capable of synthesizing antibody-drug conjugates. It can also be used as an alkyl chain-based PROTAC linker for the synthesis of PROTACs.
Biological Activity:
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Application
ORID products are tested extensively in-house and supplied worldwide to the Life Sciences industries.
Related Products
ORID products are tested extensively in-house and supplied worldwide to the Life Sciences industries.
Company Profile
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