Fmoc-Arg(Pbf)-OH CAS 154445-77-9
Fmoc-Arg(Pbf)-OH CAS 154445-77-9
Fmoc-Arg(Pbf)-OH, N-α-Fmoc-N G-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine
Description:
High purity Fmoc-protected amino acid for research and process production of peptides, with very low levels of dipeptide, free-amino acids and acetic acid impurities.
The standard derivative for the introduction of Arg in Fmoc SPPS . The Pbf side-chain protecting group is removed with TFA approximately 1-2 times faster than Pmc.In the preparation of peptides containing both Arg and Trp, it is recommended that this derivative is used in conjunction with Fmoc-Trp(Boc)-OH.
Application:
Syntheses of cyanophycin segments for investigations of cell-penetration: Describes the synthesis process and overall yields for steps from Fmoc-Arg(Pbf)-OH to Adp building blocks. (M Grogg, D Hilvert, D Seebach, 2019).
Revisiting NO2 as Protecting Group of Arginine in Solid-Phase Peptide Synthesis: Compares the stability of Fmoc-Arg(Boc) 2 -OH with Fmoc-Arg(Pbf)-OH in solvents over time. (M Alhassan, A Kumar, J Lopez, F Albericio, 2020).
Gene delivery of PAMAM dendrimer conjugated with the nuclear localization signal peptide originated from fibroblast growth factor 3: Discusses a conjugation reaction involving Fmoc-Arg(pbf)-OH in gene delivery systems.
| Empirical Formula (Hill Notation): | C34H40N4O7S |
| CAS Number: | 154445-77-9 |
| Molecular Weight: | 648.77 |
| MDL number: | MFCD00235804 |
| UNSPSC Code: | 12352209 |
| NACRES: | NA.22 |
| Assay | ≥98% (TLC) |
| ≥99.0% (HPLC) | |
| form | powder |
| reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
| mp | >65 °C |
| application(s) | peptide synthesis |
| functional group | Fmoc |
| storage temp. | -10 to -25°C |
| SMILES string | [S](=O)(=O)(N\C(=N\CCC[C@H](NC(=O)OCC3c4c(cccc4)c5c3cccc5)C(=O)O)\N)c1c(c2c(c(c1C)C)OC(C2)(C)C)C |
| InChI | 1S/C34H40N4O7S/c1-19-20(2)30(21(3)26-17-34(4,5)45-29(19)26)46(42,43)38-32(35)36-16-10-15-28(31(39)40)37-33(41)44-18-27-24-13-8-6-11-22(24)23-12-7-9-14-25(23)27/h6-9,11-14,27-28H,10,15-18H2,1-5H3,(H,37,41)(H,39,40)(H3,35,36,38)/t28-/m0/s1 |
| InChI key | HNICLNKVURBTKV-NDEPHWFRSA-N |
Application
ORID products are tested extensively in-house and supplied worldwide to the Life Sciences industries.
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ORID products are tested extensively in-house and supplied worldwide to the Life Sciences industries.
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