Fmoc-Lys(ivDde)-OH CAS 204777-78-6
Fmoc-Lys(ivDde)-OH CAS 204777-78-6
Fmoc-Lys(ivDde)-OH, N-α-Fmoc-N-ε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl-L-lysine
| Empirical Formula (Hill Notation): | C34H42N2O6 |
| CAS Number: | 204777-78-6 |
| Molecular Weight: | 574.71 |
| MDL number: | MFCD01631658 |
| UNSPSC Code: | 12352209 |
| NACRES: | NA.22 |
| Assay | ≥85.0% (acidimetric) |
| ≥97% (TLC) | |
| ≥99.0% (HPLC) | |
| form | powder |
| reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
| application(s) | peptide synthesis |
| functional group | amine |
| storage temp. | -10 to -25°C |
| SMILES string | N([C@@H](CCCCNC(=C4C(=O)CC(CC4=O)(C)C)CC(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3 |
| InChI key | PYCBVLUBTMHNPW-MHZLTWQESA-N |
Description:
Fmoc-lys(IVDDE)-OH is a kind of FMOC (9H-fluoren-9-ylmethoxycarbon) and N-IVDDE (1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butyl) double protected amino acid (lysine). It is important during peptide manufacturing. It is mainly used for the production of peptides which required to be modified on the Lysine side chain, including peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys side chain. It can also be used for the manufacturing of anionic cell penetrating peptide which is useful for intracellular delivery of therapeutic agents such as proteins and nucleic acids. The IVDDE group can be conveniently removed thorough hydrazine in the presence of acid labile groups.
Application:
Fmoc-Lys(ivDde)-OH is especially useful for preparing peptides selectively modified on the Lys sidechain, such as peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys sidechain. The ivDde protective group possesses higher orthogonality regarding Boc and Fmoc in comparison to Dde. The ivDde group can be selectively removed with hydrazine in the presence of acid labile groups such as t-butyl and trityl based protecting groups.
Application
ORID products are tested extensively in-house and supplied worldwide to the Life Sciences industries.
Related Products
ORID products are tested extensively in-house and supplied worldwide to the Life Sciences industries.
Company Profile
The capabilities of a chemical company that possesses both production and research and development (R&D) capabilities include
Freequently Asked Question..?
We place a high value on the trust our customers and partners put in us. We ensure confidentiality through non-disclosure agreements and by employing stringent data protection measures across all stages of our business interactions. Your proprietary information is safeguarded with the utmost care and discretion.
Lead times can vary based on product type, availability, and order volume. Generally, we aim to process orders within 4-6 weeks from the date of confirmation. We also offer expedited services for urgent requirements. Please contact our sales team for specific lead times related to your order.
Absolutely. We specialize in developing customized chemical solutions tailored to our clients’ specific needs. Our expert R&D team works closely with clients to understand their requirements and deliver products that meet their exact specifications. For customization inquiries, please reach out to our technical support team.
We are happy to provide samples for testing and evaluation purposes. To request a sample, please visit our website’s “Contact Us” page, and fill out the request form with details about your needs and the specific product you are interested in. Our sales team will follow up with you to arrange the delivery of the sample.
